Lazy Leukocyte Syndrome—an Enigma Finally Solved?

The staurolite enigma solved.

Staurolite has been long considered an enigma because of its remarkable pseudosymmetry and the frequent twinning. Staurolite gives two twins whose occurrence frequency seems to contradict the condition of lattice restoration requested by the reticular theory of twinning, in that the more frequent one (Saint Andrews cross twin) has a twin index of 12, whereas the less frequent one (Greek cross t...

A hospital facility layout problem finally solved

This paper presents a history of a difficult facility layout problem that falls into the category of the Koopmans-Beckmann variant of the Quadratic Assignment Problem (QAP), wherein 30 facilities are to be assigned to 30 locations. The problem arose in 1972 as part of the design of a German university hospital, Klinikum Regensburg. This problem, known as the Krarup30a upon its inclusion in the ...

Leukocyte adhesion deficiency syndrome: a controversy solved.

Sadly, mistakes of nature are often our greatest learning tools. Such is the case with the recent description by three independent groups of the molecular etiology of leukocyte adhesion deficiency (LAD) syndrome III.1–3 The discovery that mutations in kindlin-3 are responsible for this rare genetic disorder teaches us a great deal about how leukocytes regulate adhesion and trafficking through t...

[Electrocardiography and posterior wall infarction: has the enigma been solved?].

The cause of sarcoidosis: the Centurial enigma solved.

I am an experienced pathologist (4 decades), and I can now confidently perceive the cause of sarcoidosis. I can see clearly now because of 2 things: (1) modern evidence indicating a genetic-based immune dysregulation as an essential predisposing causal cofactor and (2) a century of accumulated pathology observations relevant to the point. The first factor helps explain numerous environmental, c...